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GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction | Nature Reviews Gastroenterology & Hepatology

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Somatostatin, secreted from pancreatic γ-cells, acts as an inhibitory paracrine to suppress glucagon release from pancreatic α-cells, and specific blockade of SSRT2 eliminates the inhibitory effect of GLP-1 on glucagon secretion

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